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Methiothepin maleate
CAS No. 19728-88-2
Methiothepin maleate( Methiothepin Maleate | Metitepine | HCVIN281816 )
Catalog No. M18192 CAS No. 19728-88-2
Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 56 | Get Quote |
|
| 100MG | 102 | Get Quote |
|
| 500MG | 381 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMethiothepin maleate
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NoteResearch use only, not for human use.
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Brief DescriptionMethiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
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DescriptionMethiothepin Maleate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.
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In VitroMethiothepin maleate is a 5-HT receptor antagonist, with pKds of 7.10, 7.28, 7.56, and 6.99 for 5-HT1A, 5HT1B, 5HT1C, 5HT1D. Methiothepin mesylate also shows pKds of 7.0, 7.8, 8.74, and 8.99 for 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7, respectively. Methiothepin exhibits high affinity at 5-HT2A, 5HT2B, and 5HT2C with pKis of 8.50, 8.68, and 8.35, respectively.
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In Vivo——
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SynonymsMethiothepin Maleate | Metitepine | HCVIN281816
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PathwayOthers
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TargetOther Targets
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Recptor5-HT1|5-HT6|5-HT7
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Research Area——
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Indication——
Chemical Information
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CAS Number19728-88-2
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Formula Weight472.62
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Molecular FormulaC24H28N2O4S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC.C(=CC(=O)O)C(=O)O
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Chemical Name1-Methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine Maleate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Knight J A, etal. Molecular Pharmacology, 2009, 75(2):374-380.
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