Methiothepin maleate( Methiothepin Maleate | Metitepine | HCVIN281816 )

Catalog No. M18192 CAS No. 19728-88-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Methiothepin maleate
Note

Research use only, not for human use.
Brief Description

Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Description

Methiothepin Maleate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.
In Vitro

Methiothepin maleate is a 5-HT receptor antagonist, with pKds of 7.10, 7.28, 7.56, and 6.99 for 5-HT1A, 5HT1B, 5HT1C, 5HT1D. Methiothepin mesylate also shows pKds of 7.0, 7.8, 8.74, and 8.99 for 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7, respectively. Methiothepin exhibits high affinity at 5-HT2A, 5HT2B, and 5HT2C with pKis of 8.50, 8.68, and 8.35, respectively.
In Vivo

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Synonyms

Methiothepin Maleate | Metitepine | HCVIN281816
Pathway

Others
Target

Other Targets
Recptor

5-HT1|5-HT6|5-HT7
Research Area

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Indication

——

CAS Number

19728-88-2
Formula Weight

472.62
Molecular Formula

C24H28N2O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC.C(=CC(=O)O)C(=O)O
Chemical Name

1-Methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine Maleate

1. Knight J A, etal. Molecular Pharmacology, 2009, 75(2):374-380.

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